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|Trade names||Cafergot, Ergomar|
|Pregnancy category||US: X (Contraindicated)|
|Routes of administration||Oral|
|ATC code||N02CA02 ( WHO )|
|Legal status||AU: S4 (Prescription only) CA : Schedule VI UK: POM (Prescription only) US: ℞-only DEA controlled precursor|
|Bioavailability||Intravenous: 100%,  Intramuscular: 47%,  Oral: <1%  (Enhanced by co-administration of caffeine  )|
|Elimination half-life||2 hours |
|Excretion||90% biliary |
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What class is ergotamine?
Nitial dose: 2 tablets orally at first sign of an attack; 1 additional tablet every half-hour as needed not to exceed maximum doses Initial dose: 1 suppository rectally at first sign of a migraine attack; 1 additional suppository may be ergotamine dihydroergotamine after 1 hour if needed for full relief Maximum dose: 2 suppositories per attack; 5 suppositories per 7-day period Use: To abort or prevent vascular headaches, such as a migraine, ergotamine dihydroergotamine variants, or "histaminic cephalalgia".
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If pain or symptoms persist after 30 minutes, ergotamine dihydroergotamine additional 1 mg may be administered every 30 minutes. Though most effective when taken at the onset of symptoms, it may still ease symptoms if taken at later stages.heck the labels on all your medicines e.
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Coadministration of ergotamine ergotamine dihydroergotamine potent CYP 3A4 inhibitors such as protease inhibitors or macrolide antibiotics has been associated with serious adverse events; for this reason, these drugs should not be given concomitantly with ergotamine.Limit alcoholic beverages.
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