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Clinical data
Trade namesCafergot, Ergomar
Pregnancy categoryUS: X (Contraindicated)
Routes of administrationOral
ATC codeN02CA02 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : Schedule VI UK: POM (Prescription only) US: ℞-only DEA controlled precursor
Pharmacokinetic data
BioavailabilityIntravenous: 100%, [2] Intramuscular: 47%, [1] Oral: <1% [3] (Enhanced by co-administration of caffeine [2] )
MetabolismHepatic [1]
Elimination half-life2 hours [1]
Excretion90% biliary [1]

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Nitial dose: 2 tablets orally at first sign of an attack; 1 additional tablet every half-hour as needed not to exceed maximum doses Initial dose: 1 suppository rectally at first sign of a migraine attack; 1 additional suppository may be ergotamine dihydroergotamine after 1 hour if needed for full relief Maximum dose: 2 suppositories per attack; 5 suppositories per 7-day period Use: To abort or prevent vascular headaches, such as a migraine, ergotamine dihydroergotamine variants, or "histaminic cephalalgia".

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