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Because of the higher risk of thromboembolic disease in tobacco smoking women, women should be advised not to smoke, particularly if they are over the age of 35 years.

Hormonal contraceptives and hormone replacement therapies should also be used cautiously in patients with history of coronary artery disease, progestin intolerance, or cerebrovascular disease.Endocrinology: Adult and Pediatric 7th ed. Philadelphia: Saunders Elsevier.

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