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A 10 day arm with standard triple therapy OAC; 20 mg of omeprazole /12 h, 1 g of ... RECOMMENDATION: Patients should immediately contact their healthcare professional and seek care if they take PPIs and develop diarrhea that does not improve. Information for Healthcare Professionals: A diagnosis of CDAD should be considered for PPI users with diarrhea that does not improve.

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Cisapride or metoclopramide therapy appears to provide symptomatic relief and esophageal healing as effectively as a standard dosage of a histamine H2-receptor antagonist, and improved efficacy has been reported when a prokinetic agent has been used in combination with a histamine H2-receptor antagonist. Bethanechol, a cholinergic drug that increases GI motility, may increase is omeprazole and nexium the same esophageal sphincter pressure to a small degree, but the ACG states that the drug has limited efficacy in the treatment of GERD.There is no scientific data to guide physicians on how to deal with the relatively few patients that have side effects from one of the PPIs.

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Per 1000 patient months of exposure Adverse events that occurred significantly more often in the first month of treatment with esomeprazole compared with months 2-6 included diarrhoea, nausea/vomiting, abdominal pain, dyspepsia, headache/migraine, intolerance, malaise/lassitude, pruritus, unspecified adverse effects and abnormal sensation.

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