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Hese symptoms generally subside within 2 to 3 months following discontinuation of Metoclopramide.In elderly patients a dose reduction should be considered, based on renal and metoclopramide for migraine function and overall metoclopramide for migraine. In patients with end stage renal disease Creatinine clearance 15 ml/min the daily dose should be reduced by 75 In patients with moderate to severe renal impairment Creatinine clearance 15-60 ml/min the dose should be reduced by 50% see section 5.

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